Products
CD44 antibody
Category:
Research Area:
- SPECIFICATIONS
- Product Name
- CD44 antibody
- Catalogue No.
- FNab01483
- Size
- 100μg
- Form
- liquid
- Purification
- Protein A+G purification
- Purity
- ≥95% as determined by SDS-PAGE
- Clonality
- monoclonal
- Isotype
- IgG2a
- Clone ID
- 7D6
- Storage
- PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.)
Immunogen
- Immunogen
- CD44 molecule(Indian blood group)
- Alternative Names
- LHR antibody, MDU2 antibody, MDU3 antibody, MIC4 antibody
- UniProt ID
- P16070
- Observed MW
- 80-95 kDa
Application
- Tested Applications
- ELISA, WB, IHC, IF, FC
- Recommended dilution
- WB: 1:500-1:5000; IHC: 1:50-1:200; IF: 1:10-1:100
Validated Images
HeLa cells were subjected to SDS PAGE followed by western blot with FNab01483(CD44 antibody) at dilution of 1:1000
Immunohistochemistry of paraffin-embedded human lung cancer slide using FNab01483(CD44 Antibody) at dilution of 1:50
- Background
- Receptor for hyaluronic acid(HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases(MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9; the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T(iTreg) cell stability and suppressive function(By similarity).